e-Learn @ SASTRA Back

Importance of C, General introduction of structure of molecules

Atomic orbitals, filling of AO, Octet rules, Types of bonds

Types of bond, electronic structure of molecules, Aos and introduction to MOT

Mot & disadvantages, VSEPR theory, Structural prediction of molecules, Methane, ethane, ethylene, acetylene using VSEPR theory

Bond Angle, Length and Energy and introduction to resonance

Resonance, Rules of resonance, Mesomeric Effect

Steric inhibition to resonance, Cross-conjugation and introduction to hyperconjugation

Hyper conjugation, Tautomerism

Tautomerism - Different types other than Keto-Enol tautomerism. H-bonding & its importance. Acid-Base concept. Introduction to Bronsted acid-base theory

Mechanism of Bronsted Acid-Base theory. Lewis theory-HSAB principle, Factor affecting Acid-base theory

Structure based relationship on acidity & basicity

Introduction- criteria for Aromatic, non-aromatic and anti-aromatic compounds, 2 and 6 electron system

Aromaticity-Other aromatic sextet, Azulene, [10] Annulenes, Anti-aromaticity- 4 electron system

Hetero aromatic system, Annellation, Partial bond fixation, Tropylium cation, Cycloheptatriene as homo-aromatic system

Anti-aromatic - 8 electron system, Aromaticity - 14 and 18 electron system

Aromaticity - Kekulenes, Phenacenes, Cycloacenes, [12] Annulenes, [16] Annulenes

Other classes of Aromatic compounds - Mesoionic compounds, Dianion of squaric acid, Homo aromatic compounds & Fullerenes & Bucky balls, Unit 2- Reactive intermediates

Carbocation - Stability, Structure, Methods of generation

Carbocation - Reactivity, Carbanion - Stability

Carbanion - Stability, reactivity and methods of generation, Carbene - Types of carbene - Singlet and triplet carbenes, Methods of generation

Reactive Intermediates - Carbenes and Nitrenes

Reactive Intermediates - Free radicals

Reaction Mechanism - Introduction, Thermodynamic and Kinetic requirement for a chemical reaction

Kinetics Vs Thermodynamic controlled reaction & product, Hammond Postulate & Principle of microscopic reversibility

Curtin-Hammett principle, Isotope effects - Primary & secondary isotope effects, solvent isotope effects

Hammett relationship - Substituent constant and reaction constant

Hammett reaction constant, Reaction where RHo is -ve and low value, Taft equation, isotope labelling in finding out whether rxn is intra or inter-molecular

Cross-over product, Nucleophile-introduction

Nucleophile - Ambident nucleophile, regioselectivity, Alpha effect, Electrophile -Trigonal & tetrahedral electrophile, Ambident electrophile

Unit-3 Stereochemistry- introduction, Different types of isomers, Prochiral carbon, Chiral carbon, Perspective diagram and fischer projection

R, S configuration of chiral compounds

Optical Purity, Absolute & relative configuration

Absolute configuration of (+)-glyceraldehyde, Plane and center of symmetry, Sawhorse and Newmann projection & their interconversion

Fischer to Sawhorse and Newmann projection, Molecules with more than 1 asymmetric carbon, Meso compounds, Enantiotopic hydrogen

Stereochemistry- Diastereotopic hydrogen, groups, faces, Enatiotopic faces. Regioselective reaction, Stereoselective and stereospecific reaction

Stereochemistry of bromine addition, hydrogen addition, hydroboration-oxidation reaction

Optical isomerism of compounds with N, S or P containing compounds, Geometrical isomerism - E and Z isomerism

Geometrical isomerism of cumulenes and oximes, Physical and spectral properties of geometrical isomers, Determination of configuration of geometrical isomers

Geometrical isomerism of monocyclic and fused ring systems, Atropisomerism of biphenyl - Examples.

Atropisomerismsss-Define, R, S configuration of Atropisomere, Optical activity of allenes

Allenes- R, S configuration, Spiranes - Preparations and R, S configuration, Introduction to nuceohilic substitution Reaction

SN2 reaction, factors affecting SN2 reactions-Substrate, leaving group, nucleophile,SN1 reaction, factors affecting SN1 reaction- Alkyl halide

Factors affecting SN1 reaction, Difference between SN1 and SN2 reaction, Reactivity of vinylic and aryl halides, Allylic and benzylic halide, Rearrangement in SN1 reaction, SNi reaction

Nucleophilic substitution at Norbornyl and bridgehead system, Neighboring group participation, Nucleophilic substitution at Carbonyl carbon

Examples of various nucleophilic substitution reactions with mechanism - Ester hydrolysis catalysed by acid and Base, Halogen exchange reaction, Alkylation & acylation of amines

Aliphatic Nucleophilic substitution - Reaction of active methylene groups - Dehalogenation, Acylation, Claisen Condensation, Dieckmann condensation,Nucleophilic Aromatic substitution reaction - Introduction

SNAr reaction, Meisenheimer complex, Benzyne mechanism, Direct & cine substitution, Chichibabin reaction, SEAr reaction - introduction

SEAr reaction, Effect of substituents on reactivity, inductive electron donation & withdrawal, electron donation & withdrawal by resonance, relative reactivity

Effect of substituents on orientation - inductive electron donating, resonance electron donating, Inductive and resonance electron withdrawing, ortho-para ratio, ortho effect

Friedel Craft's alkylation and acylation reaction - Mechanism and limitation, Vilsmeier- Haack Reaction, Gattermann-koch reaction

Electrophilic substitution reaction: Diazonium coupling, Ipso attack, SE1 and SE2 reaction, Addition reaction: Types, Electrophilic addition reaction with examples

Regioselectivity in Electrophilic addition Reaction, Markovnikov's product, Rearrangement of carbocation, Hydroboration-Oxidation reaction, Example

Hydroboration-oxidation reaction, Stereochemistry of addition reaction, Free radical addition - peroxide effect, Michael addition and Robinson annulation

Conjugate addition to alpha, beta-unsaturated carbonyl compounds- Gilmann reagent and grignard reagent, Elimination reaction - E2 reaction- Regioselectivity

Deviation from Zaitsev's rule - COnjugate alkene, Presence of alkyl fluorides, Bulky bases, E1 Reaction - Mechanism, Relative stability of alkyl halides, Carbocation rearrangement, Competition between E1 and E2 reactions, Stereochemistry of E2 reaction.

Stereochemistry of E2 elimination- Anti elimination, Stereoselectivity in E2 reaction - E Vs Z alkene stability, Stereochemistry of the E1 Reaction, Elimination from Cyclic Compounds - E1 and E2

Competition between Substitution and elimination, SN2 vs E2, SN1 vs E1, Pyrolytic elimination, Chugaev and cope elimination

Shapiro Elimination and mechanism, Hofmann exhaustive methylation and Hofmann eimination reaction - Regioselectivity.

Cram's law of asymmetric induction, Revision on elimination reaction

Revision on Aromatic substitution reaction-SNAr reaction, Benzyne mechanism, Chichibabin reaction, SEAr reaction, Effect of subn on orientation and reactivity, Ortho effect

Revision on Substitution- SEAr, and Aliphatic Nucleophilic substitution reaction

Revision of old Question papers